Long lines @ the gas pumps in #Napa. Power outages pushing people to prepare pic.twitter.com/FjnrEVEWaz— Lisa Amin Gulezian (@LisaAminABC7) October 9, 2019 Southern California could be impacted, too, as gusty winds move in later in the week.A preemptive shutdown in Southern California would be historic — Southern California Edison incident commander Terry Ohanian said he’s been with the company for over 35 years and they have never attempted a preemptive shut down like this before. Public Safety Power Shutoff in Marin is underway. Currently no traffic lights at the intersection of N. Bridge and Bridgway Blvd in Sausalito/Marin City. Please use caution and treat outages at traffic lights as 4-way stops. #MarinPSPS #pgeshutoff pic.twitter.com/ZVxJfyXOnj— Marin County Sheriff (@MarinSheriff) October 9, 2019 Very dry and gusty #SantaAnaWinds are expected late Wed night-Fri afternoon over LA/Ventura counties. A Red Flag Warning has been issued for most of LA and VTA counties effective 3am Thu-6pm Fri. Use extreme caution with potential ignition sources! #SoCal #CAwx #CAfire pic.twitter.com/RSX3BdC5yL— NWS Los Angeles (@NWSLosAngeles) October 8, 2019 In Napa County, police had to step in when a battery backup failed at a busy intersection. “We won’t just de-energize for the sake of doing it,” Ohanian told ABC News Wednesday morning. “We know it’s an inconvenience for our customers so we try to be thoughtful about what we do, but the potential is there.”“And unlike a planned outage where we can schedule it for a certain period of time, this is a function of when the wind blows and when the weather materializes,” he said. #DEVELOPING When the backup to the backup fails, it’s time for the humans to step in. That’s exactly what #CHP is doing at the busy intersection of Highway 29 an 221 in #Napa Co. The battery backup failed to keep the traffic signals working. pic.twitter.com/Ah4tlFAlxo— Laura Anthony (@LauraAnthony7) October 9, 2019 Storm Prediction Center has portions of the North Bay and Northern California in it’s rare “Extreme” Fire Wx Outlook for later today. #CAwx #OneLessSpark #FireWeather #RedFlagWarning pic.twitter.com/e20yAzGdP3— NWS Bay Area (@NWSBayArea) October 9, 2019 Some helpful tips when preparing for Public Power Safety Shutoffs. #CAwx pic.twitter.com/AVBwiZDytq— NWS Bay Area (@NWSBayArea) October 9, 2019 Dark gas station on Bridgeway in Sausalito. Power outage is in effect in parts of the North Bay pic.twitter.com/0276jl7mxP— Amy Hollyfield (@amyhollyfield) October 9, 2019 “We understand the effects this event will have on our customers and appreciate the public’s patience as we do what is necessary to keep our communities safe and reduce the risk of wildfire,” Michael Lewis, PG&E’s senior vice president of Electric Operations, said in a statement. milehightraveler/iStock(SAN FRANCISCO) — As California faces a critical fire danger, utility companies are preemptively shutting off power to hundreds of thousands of customers in the Golden State.The outages come as a way to reduce the risk of wildfire, as winds — which contribute to blazes — pick up throughout the state.Last year’s Camp Fire, the deadliest fire in California’s history, was sparked by power lines owned and operated by Pacific Gas and Electric, according to Cal Fire. The fire, which originated near Pulga in Northern California in Nov. 2018, killed dozens.A PG&E meteorologist said the weather forecast this week is the strongest wind event since the Oct. 2017 North Bay fires which were caused by “electric power and distribution lines, conductors and the failure of power poles,” reported ABC San Francisco station KGO.In Northern California, where winds were picking up Wednesday morning, 480,000 customers were without power as of 5 a.m. local time Wednesday.In four Northern California counties — Humboldt, Lake, Placer and Napa — over 75 percent of customers lost power. Another angle of the #BriceburgFire from an alternate PG&E camera. pic.twitter.com/y8uXCbCqHo— NWS Hanford (@NWSHanford) October 8, 2019 In Sausalito, just outside San Francisco, two dental hygienists were frustrated to arrive to the office and find no power. They also found it difficult to access the latest PG&E status online.“We understand that they’re doing what they have to do in a way, but trying to find out information has been the most frustrating, so we really don’t know day to day how to plan,” one employee told ABC News.It could take several days to fully restore power, PG&E officials said Tuesday night.More waves of shutoffs are coming, and a total of 800,000 Northern and Central California customers are expected to be impacted, PG&E officials said Tuesday night.Local school districts as well as UC Berkeley have canceled classes due to the outages. Ohanian said 170,000 Southern California Edison customers may be impacted.The California Highway Patrol is reminding drivers that if a traffic light is flashing, treat it as a stop sign intersection. If the light is out, treat as an all-way stop.Copyright © 2019, ABC Audio. All rights reserved.
Proteins don’t usually work in isolation, but rather make up larger complexes such as molecular machines that enable cells to communicate with each other, move cargo around in their interiors, or replicate their DNA.Yet even with the advent of super-resolution microscopy, the technology has not been powerful enough to distinguish individual molecular features within those densely packed complexes. Up to now, researchers only have been able to visualize closely positioned molecules or molecular complexes with 10 to 20 nanometer resolution.But by advancing technology, a team at Harvard’s Wyss Institute for Biologically Inspired Engineering has been able to distinguish features 5 nanometers from each other in a densely packed, single-molecular structure, achieving the highest resolution in optical microscopy. The team, led by Wyss core faculty member Peng Yin, used “discrete molecular imaging” (DMI), which enhances its DNA nanotechnology-powered, super-resolution microscopy platform with an integrated set of new imaging methods. The study was reported in Nature Nanotechnology on July 4.Super Resolution Discrete Molecular Imaging Animation <a href=”https://www.youtube.com/watch?v=5ChCYOEQwTc” rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/5ChCYOEQwTc/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> <a href=”https://www.youtube.com/watch?v=iLyTEb4qYz8″ rel=”nofollow” target=”_blank”> <img src=”https://img.youtube.com/vi/iLyTEb4qYz8/0.jpg” alt=”0″ title=”How To Choose The Correct Channel Type For Your Video Content ” /> </a> See in this animation how Discrete Molecular Imaging (DMI) uses DNA nanotechnology to reveal densely packed molecular features in structures as similar in size as single protein molecules. Credit: Wyss Institute at Harvard University.“The ultra-high resolution of DMI advances the DNA-PAINT platform one step further towards the vision of providing the ultimate view of biology,” said Peng Yin, who is also professor of systems biology at Harvard Medical School.Thee DNA-PAINT technologies developed by Yin and his team are based on the transient binding of two complementary short DNA strands: one attached to the molecular target that the researchers aim to visualize, and the other attached to a fluorescent dye. Repeated cycles of binding and unbinding create a very defined blinking behavior of the dye at the target site, which is highly programmable by the choice of DNA strands and has now been further harnessed by the team’s current work to achieve ultra-high resolution imaging.Discrete Molecular Imaging Wyss Institute Core Faculty member Peng Yin and his co-worker Mingjie Dai explain in this video, how Discrete Molecular Imaging (DMI) can be used to enhance their DNA-PAINT super-resolution imaging platform to visualize features on a single-molecule scale. Credit: Wyss Institute at Harvard University“Peng Yin and his team have yet again broken through barriers never before possible by leveraging the power of programmable DNA, not for information storage, but to create nanoscale ‘molecular instruments’ that carry out defined tasks and read out what they analyze. This new advancement to their DNA-powered super-resolution imaging platform is an amazing feat that has the potential to uncover the inner workings of cells at the single-molecule level using conventional microscopes that are available in common biology laboratories,” said Donald Ingber, Judah Folkman Professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children’s Hospital, and professor of bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences.The Wyss Institute’s scientists have benchmarked the ultra-high resolution of DMI using synthetic DNA nanostructures. Next, the researchers plan to apply the technology to actual biological complexes such as the protein complex that duplicates DNA in dividing cells or cell surface receptors binding their ligands.To read the full release, visit the Wyss Institute’s website.— Benjamin Boettner, Wyss Institute Communications